1,5-Naphthalenediamine: Target Organs and Levels of Evidence for TR-143
Bioassay of 1,5-Naphthalenediamine for Possible Carcinogenicity (CASRN 2243-62-1)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
1,5-Naphthalenediamine
2243-62-1 | 06/29/1978 | Dosed-Feed
R: 0,.05,1.0, M: 0,.1,.2 %/50 PER GROUP | T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: Negative
Female Rats: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Clitoral Gland:
(ADENOMA OR CARCINOMA)
- Uterus/Cervix:
(POLYP)
|
Male Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Thyroid Gland Follicular Cell:
ADENOMA
|
Female Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Thyroid Gland C-Cell:
ADENOMA OR CARCINOMA, ADENOMA
- Liver:
(ADENOMA, CARCINOMA)
- Lung:
(ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA)
|
