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Nithiazide: Target Organs and Levels of Evidence for TR-146

Bioassay of Nithiazide for Possible Carcinogenicity (CASRN 139-94-6)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Nithiazide 139-94-6	10/25/1978	Dosed-Feed R: 0,625,1250, M: 0,2500,5000 PPM/50 PER GROUP	Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Negative

Female Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Mammary Gland: (FIBROADENOMA OR CYSTADENOMA) Skin: (FIBROADENOMA OR CYSTADENOMA)

Male Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: (ADENOMA OR CARCINOMA)

Female Mice: Equivocal

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: (ADENOMA OR CARCINOMA)