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o-Toluidine hydrochloride: Target Organs and Levels of Evidence for TR-153

Bioassay of o-Toluidine Hydrochloride for Possible Carcinogenicity (CASRN 636-21-5)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
o-Toluidine hydrochloride 636-21-5	10/25/1978	Dosed-Feed R: 0,3000,6000, M: 0,1000,3000 PPM/50 PER GROUP	Frederick Cancer Research Facility

Levels of Evidence

Male Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Spleen: (SARCOMA) Mesothelium (Abdominal Cavity/Tunica Vaginalis): MESOTHELIOMA Subcutaneous Tissue: (FIBROMA)

Female Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Spleen: (SARCOMA) Urinary Bladder: (TRANSITIONAL CELL CARCINOMA) Mammary Gland: (ADENOMA OR FIBROADENOMA)

Male Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Vascular System (Unspecified): HEMANGIOSARCOMA

Female Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: (ADENOMA OR CARCINOMA)