https://ntp.niehs.nih.gov/go/6199

o-Toluidine hydrochloride: Target Organs and Levels of Evidence for TR-153

Bioassay of o-Toluidine Hydrochloride for Possible Carcinogenicity (CASRN 636-21-5)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
o-Toluidine hydrochloride
636-21-5		 10/25/1978 Dosed-Feed
R: 0,3000,6000, M: 0,1000,3000 PPM/50 PER GROUP		 Frederick Cancer Research Facility

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Spleen: (SARCOMA)
  • Mesothelium (Abdominal Cavity/Tunica Vaginalis): MESOTHELIOMA
  • Subcutaneous Tissue: (FIBROMA)
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Spleen: (SARCOMA)
  • Urinary Bladder: (TRANSITIONAL CELL CARCINOMA)
  • Mammary Gland: (ADENOMA OR FIBROADENOMA)
Male Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Unspecified): HEMANGIOSARCOMA
Female Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (ADENOMA OR CARCINOMA)