o-Toluidine hydrochloride: Target Organs and Levels of Evidence for TR-153
Bioassay of o-Toluidine Hydrochloride for Possible Carcinogenicity (CASRN 636-21-5)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
o-Toluidine hydrochloride
636-21-5 | 10/25/1978 | Dosed-Feed
R: 0,3000,6000, M: 0,1000,3000 PPM/50 PER GROUP | Frederick Cancer Research Facility |
Levels of Evidence
Male Rats: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Spleen:
(SARCOMA)
- Mesothelium (Abdominal Cavity/Tunica Vaginalis):
MESOTHELIOMA
- Subcutaneous Tissue:
(FIBROMA)
|
Female Rats: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Spleen:
(SARCOMA)
- Urinary Bladder:
(TRANSITIONAL CELL CARCINOMA)
- Mammary Gland:
(ADENOMA OR FIBROADENOMA)
|
Male Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Vascular System (Unspecified):
HEMANGIOSARCOMA
|
Female Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
(ADENOMA OR CARCINOMA)
|
