Skip to Main Navigation Skip to Page Content

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

2,4-Diaminotoluene (2,4-toluene diamine): Target Organs and Levels of Evidence for TR-162

Bioassay of 2,4-Diaminotoluene for Possible Carcinogenicity (CASRN 95-80-7)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
2,4-Diaminotoluene (2,4-toluene diamine) 95-80-7	12/13/1978	Dosed-Feed MR: 0,79,176 (AVG), FR: 0,79,171 (AVG), M: 0,100,200 PPM/50 PER GROUP	Frederick Cancer Research Facility

Levels of Evidence

Male Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: (NEOPLASTIC NODULE, CARCINOMA)

Female Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Mammary Gland: (ADENOMA, CARCINOMA) Liver: (NEOPLASTIC NODULE, CARCINOMA)

Male Mice: Negative

Female Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: (CARCINOMA)
May Have Been Related	Hematopoietic System: (LYMPHOMA)