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Michler's ketone: Target Organs and Levels of Evidence for TR-181

Bioassay of Michler's Ketone for Possible Carcinogenicity (CASRN 90-94-8)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Michler's ketone 90-94-8	10/25/1978	Dosed-Feed MR: 0,250,500, FR: 0,500,1000, M: 0,1250,2500 PPM/50 PER GROUP	Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: (CARCINOMA)

Female Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: (CARCINOMA)

Male Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Vascular System (Unspecified): HEMANGIOSARCOMA

Female Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: (CARCINOMA)