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4,4'-Methylenebis(N,N-dimethyl)benzenamine: Target Organs and Levels of Evidence for TR-186

Bioassay of 4,4'-Methylenebis-(N,N-dimethyl)benzeneamine for Possible Carcinogenicity (CASRN 101-61-1)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
4,4'-Methylenebis(N,N-dimethyl)benzenamine 101-61-1	10/25/1978	Dosed-Feed R: 0,375,750, M: 0,1250,2500 PPM/50 PER GROUP	Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Thyroid Gland Follicular Cell: CARCINOMA

Female Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Thyroid Gland Follicular Cell: CARCINOMA

Male Mice: Equivocal

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: (ADENOMA OR CARCINOMA)

Female Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: (ADENOMA OR CARCINOMA)