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https://ntp.niehs.nih.gov/go/8415

4,4'-Methylenebis(N,N-dimethyl)benzenamine: Target Organs and Levels of Evidence for TR-186

Bioassay of 4,4'-Methylenebis-(N,N-dimethyl)benzeneamine for Possible Carcinogenicity (CASRN 101-61-1)

Chemical (Study Title)
CASRN		Peer Review DateRoute/Exposure LevelsStudy Laboratory
4,4'-Methylenebis(N,N-dimethyl)benzenamine
101-61-1		10/25/1978Dosed-Feed
R: 0,375,750, M: 0,1250,2500 PPM/50 PER GROUP		Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: CARCINOMA
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: CARCINOMA
Male Mice: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (ADENOMA OR CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (ADENOMA OR CARCINOMA)