4,4'-Methylenebis(N,N-dimethyl)benzenamine: Target Organs and Levels of Evidence for TR-186
Bioassay of 4,4'-Methylenebis-(N,N-dimethyl)benzeneamine for Possible Carcinogenicity (CASRN 101-61-1)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|
4,4'-Methylenebis(N,N-dimethyl)benzenamine 101-61-1 | 10/25/1978 | Dosed-Feed R: 0,375,750, M: 0,1250,2500 PPM/50 PER GROUP | Litton Bionetics, Inc. |
Levels of Evidence
Male Rats: Positive
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions | - Thyroid Gland Follicular Cell:
CARCINOMA
|
Female Rats: Positive
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Thyroid Gland Follicular Cell:
CARCINOMA
|
Male Mice: Equivocal
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Liver:
(ADENOMA OR CARCINOMA)
|
Female Mice: Positive
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Liver:
(ADENOMA OR CARCINOMA)
|