https://ntp.niehs.nih.gov/go/9772

4,4'-Oxydianiline: Target Organs and Levels of Evidence for TR-205

Bioassay of 4,4'-Oxydianiline for Possible Carcinogenicity (CASRN 101-80-4)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
4,4'-Oxydianiline
101-80-4		 02/15/1980 Dosed-Feed
R: 0,200,400,500, M: 0,150,300,800 PPM/50 PER GROUP		 T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (NEOPLASTIC NODULE, CARCINOMA)
  • Thyroid Gland Follicular Cell: ADENOMA OR CARCINOMA
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (NEOPLASTIC NODULE, CARCINOMA)
  • Thyroid Gland Follicular Cell: ADENOMA OR CARCINOMA
Male Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Harderian Gland: (ADENOMA)
  • Liver: (ADENOMA OR CARCINOMA)
Female Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Harderian Gland: (ADENOMA)
  • Liver: (CARCINOMA)
  • Thyroid Gland Follicular Cell: ADENOMA