1,2-Dibromo-3-chloropropane: Target Organs and Levels of Evidence for TR-206
Carcinogenesis Bioassay of 1,2-Dibromo-3-chloropropane (CASRN 96-12-8) in F344 Rats and B6C3F1 Mice (Inhalation Study)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
1,2-Dibromo-3-chloropropane
96-12-8 | 06/27/1980 | Inhalation
0,0.6,3.0 PPM/50 PER GROUP | Hazleton, Vienna |
Levels of Evidence
Male Rats: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Nasal Cavity:
BENIGN AND MALIGNANT TUMORS 0/50 32/50 39/49
- Oral Cavity:
SQUAMOUS CELL PAPILLOMA 0/50 1/50 8/49; SQUAMOUS CELL CARCINOMA 0/50 0/50 3/49
|
Female Rats: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Nasal Cavity:
BENIGN AND MALIGNANT TUMORS 1/50 21/50 32/50
- Oral Cavity:
SQUAMOUS CELL PAPILLOMA 0/50 3/50 11/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 5/50
- Adrenal Gland Cortex:
ADENOMA 0/50 7/50 5/48
|
Male Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Nasal Cavity:
BENIGN AND MALIGNANT TUMORS 0/45 1/42 21/48
- Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 0/41 1/40 6/45; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/41 2/40 1/45
|
Female Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Nasal Cavity:
BENIGN AND MALIGNANT TUMORS 0/50 11/50 38/50
- Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 3/49 10/47; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/49 2/49 4/47
|
