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2,3,7,8-Tetrachlorodibenzo-p-dioxin: Target Organs and Levels of Evidence for TR-209

Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6) in Osborne-Mendel Rats and B6C3F1 Mice (Gavage Study)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
2,3,7,8-Tetrachlorodibenzo-p-dioxin 1746-01-6	06/27/1980	Gavage R&MM: 0,.01,.05,.5 UG/KG/WK/50 PER GROUP FM: 0,.04,.2,2.0 UG/KG/WK/50 PER GROUP	IIT Research Institute

Levels of Evidence

Male Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Thyroid Gland Follicular Cell: ADENOMA 1/69 5/48 6/50 10/50

Female Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: NEOPLASTIC NODULE 5/75 1/49 3/50 12/49

Male Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: CARCINOMA 8/73 9/49 8/49 17/50

Female Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: CARCINOMA 1/73 2/50 2/48 6/47 Thyroid Gland Follicular Cell: ADENOMA 0/69 3/50 1/47 5/46