2,3,7,8-Tetrachlorodibenzo-p-dioxin: Target Organs and Levels of Evidence for TR-209
Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6) in Osborne-Mendel Rats and B6C3F1 Mice (Gavage Study)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
2,3,7,8-Tetrachlorodibenzo-p-dioxin
1746-01-6 | 06/27/1980 | Gavage
R&MM: 0,.01,.05,.5 UG/KG/WK/50 PER GROUP FM: 0,.04,.2,2.0 UG/KG/WK/50 PER GROUP | IIT Research Institute |
Levels of Evidence
Male Rats: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Thyroid Gland Follicular Cell:
ADENOMA 1/69 5/48 6/50 10/50
|
Female Rats: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
NEOPLASTIC NODULE 5/75 1/49 3/50 12/49
|
Male Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
CARCINOMA 8/73 9/49 8/49 17/50
|
Female Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
CARCINOMA 1/73 2/50 2/48 6/47
- Thyroid Gland Follicular Cell:
ADENOMA 0/69 3/50 1/47 5/46
|
