https://ntp.niehs.nih.gov/go/9780

2,3,7,8-Tetrachlorodibenzo-p-dioxin: Target Organs and Levels of Evidence for TR-209

Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6) in Osborne-Mendel Rats and B6C3F1 Mice (Gavage Study)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
2,3,7,8-Tetrachlorodibenzo-p-dioxin
1746-01-6		 06/27/1980 Gavage
R&MM: 0,.01,.05,.5 UG/KG/WK/50 PER GROUP FM: 0,.04,.2,2.0 UG/KG/WK/50 PER GROUP		 IIT Research Institute

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 1/69 5/48 6/50 10/50
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: NEOPLASTIC NODULE 5/75 1/49 3/50 12/49
Male Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 8/73 9/49 8/49 17/50
Female Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 1/73 2/50 2/48 6/47
  • Thyroid Gland Follicular Cell: ADENOMA 0/69 3/50 1/47 5/46