1,2-Dibromoethane: Target Organs and Levels of Evidence for TR-210
Carcinogenesis Bioassay of 1,2-Dibromoethane (CASRN 106-93-4) in F344 Rats and B6C3F1 Mice (Inhalation Study)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
1,2-Dibromoethane
106-93-4 | 06/27/1980 | Inhalation
0,10,40 PPM/50 PER GROUP | Hazleton, Vienna |
Levels of Evidence
Male Rats: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Nasal Cavity:
ADENOMA 0/50 11/50 0/50; ADENOCARCINOMA 0/50 20/50 28/50; CARCINOMA 0/50 0/50 21/50
- Vascular System (Unspecified):
HEMANGIOSARCOMA 0/50 1/50 15/50
- Mesothelium (Abdominal Cavity/Tunica Vaginalis):
MESOTHELIOMA 0/50 7/50 25/50
|
Female Rats: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Nasal Cavity:
ADENOMA 0/50 11/50 3/50; ADENOCARCINOMA 0/50 20/50 29/50; CARCINOMA 0/50 0/50 25/50
- Vascular System (Unspecified):
HEMANGIOSARCOMA 0/50 0/50 5/50
- Mammary Gland:
FIBROADENOMA 4/50 29/50 24/50
- Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 0/48 1/47 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/48 4/47 COMBINED 0/50 0/48 5/47
|
Male Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 0/41 0/48 11/46; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/41 3/48 19/46
|
Female Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 7/49 13/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/49 5/49 37/50
- Vascular System (Unspecified):
HEMANGIOSARCOMA 0/50 11/50 23/50
- Subcutaneous Tissue:
FIBROSARCOMA 0/50 5/50 11/50
- Nasal Cavity:
CARCINOMA 0/50 0/50 6/50
- Mammary Gland:
ADENOCARCINOMA 2/50 14/50 8/50
|
