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Di(2-ethylhexyl) Phthalate: Target Organs and Levels of Evidence for TR-217

Carcinogenesis Bioassay of Di(2-ethylhexyl)phthalate (CASRN 117-81-7) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Di(2-ethylhexyl) phthalate 117-81-7	10/15/1980	Dosed-Feed R: 0,6000,12000, M: 0,3000,6000 PPM/50 PER GROUP	T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: NEOPLASTIC NODULE 2/50 5/49 7/49 OR CARCINOMA 1/50 1/49 5/49 COMBINED 3/50 6/49 12/49

Female Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: CARCINOMA 0/50 2/49 8/50

Male Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: CARCINOMA 9/50 14/48 19/50

Female Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: CARCINOMA 0/50 7/50 17/50