https://ntp.niehs.nih.gov/go/9796

Di(2-ethylhexyl) Phthalate: Target Organs and Levels of Evidence for TR-217

Carcinogenesis Bioassay of Di(2-ethylhexyl)phthalate (CASRN 117-81-7) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
Di(2-ethylhexyl) phthalate
117-81-7
10/15/1980 Dosed-Feed
R: 0,6000,12000, M: 0,3000,6000 PPM/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: NEOPLASTIC NODULE 2/50 5/49 7/49 OR CARCINOMA 1/50 1/49 5/49 COMBINED 3/50 6/49 12/49
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 0/50 2/49 8/50
Male Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 9/50 14/48 19/50
Female Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 0/50 7/50 17/50