https://ntp.niehs.nih.gov/go/9804

C.I. Disperse Yellow 3: Target Organs and Levels of Evidence for TR-222

Carcinogenesis Bioassay of Disperse Yellow 3 (CASRN 2832-40-8) in F344 Rats and B6C3F1 Mice (Feed Study)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
C.I. Disperse yellow 3
2832-40-8		 02/18/1981 Dosed-Feed
R: 0,5000,10000, M: 0,2500,5000 PPM/50 PER GROUP		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: NEOPLASTIC NODULE 1/49 15/50 10/50
May Have Been Related
  • Glandular Stomach: ADENOMA 0/49 1/50 0/50; ADENOCARCINOMA 0/49 1/501/50; SARCOMA 0/49 0/50 1/50
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/49 1/50 0/50; FIBROSARCOMA 0/49 1/50 0/50; SARCOMA 0/49 0/50 1/50
Female Rats: Negative
Male Mice: Negative
Female Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 0/50 6/50 12/50
May Have Been Related
  • Hematopoietic System: LYMPHOMA 10/50 16/50 19/50