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Eugenol: Target Organs and Levels of Evidence for TR-223

Carcinogenesis Studies of Eugenol (CASRN 97-53-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Eugenol 97-53-0	02/18/1981	Dosed-Feed FR: 0,6000,12500, MR&M: 0,3000,6000 PPM/50 PER GROUP	Southern Research Institute

Levels of Evidence

Male Rats: Negative

Female Rats: Negative

Male Mice: Equivocal

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: ADENOMA 4/50 13/50 10/49 OR CARCINOMA 10/50 20/50 9/49 COMBINED 14/50 28/50 18/49

Female Mice: Equivocal

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: ADENOMA 0/50 4/49 3/49 OR CARCINOMA 2/50 3/49 6/49 COMBINED 2/50 7/49 9/49