https://ntp.niehs.nih.gov/go/9806

Eugenol: Target Organs and Levels of Evidence for TR-223

Carcinogenesis Studies of Eugenol (CASRN 97-53-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Eugenol
97-53-0		 02/18/1981 Dosed-Feed
FR: 0,6000,12500, MR&M: 0,3000,6000 PPM/50 PER GROUP		 Southern Research Institute

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Equivocal
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 4/50 13/50 10/49 OR CARCINOMA 10/50 20/50 9/49 COMBINED 14/50 28/50 18/49
Female Mice: Equivocal
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 0/50 4/49 3/49 OR CARCINOMA 2/50 3/49 6/49 COMBINED 2/50 7/49 9/49