Skip to Main Navigation
Skip to Page Content
COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/7140

Pentachloroethane: Target Organs and Levels of Evidence for TR-232

Carcinogenesis Studies of Pentachloroethane (CASRN 76-01-7) in F344/N Rats and B6C3F1 Mice (Gavage Study)

Chemical (Study Title)
CASRN		Peer Review DateRoute/Exposure LevelsStudy Laboratory
Pentachloroethane
76-01-7		06/23/1981Gavage
R: 0,75,150, M: 0,250,500 MG/KG/50 PER GROUP		Gulf South Research Institute

Levels of Evidence

Male Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 1/49 4/50; ADENOMA OR ADENOCARCINOMA COMBINED 1/50 2/49 4/50
Non-Neoplastic Lesions
  • KIDNEY: INFLAMMATION, CHRONIC, DIFFUSE; PAPILLA, MINERALIZATION
Female Rats: Negative
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 4/48 26/44 7/45
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 2/46 8/42 19/45; CARCINOMA 1/46 28/42 13/45