Pentachloroethane: Target Organs and Levels of Evidence for TR-232
Carcinogenesis Studies of Pentachloroethane (CASRN 76-01-7) in F344/N Rats and B6C3F1 Mice (Gavage Study)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Pentachloroethane
76-01-7 | 06/23/1981 | Gavage
R: 0,75,150, M: 0,250,500 MG/KG/50 PER GROUP | Gulf South Research Institute |
Levels of Evidence
Male Rats: Equivocal
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Kidney Tubular Cell:
ADENOMA 0/50 1/49 4/50; ADENOMA OR ADENOCARCINOMA COMBINED 1/50 2/49 4/50
|
| Non-Neoplastic Lesions | - KIDNEY: INFLAMMATION, CHRONIC, DIFFUSE; PAPILLA, MINERALIZATION
|
Female Rats: Negative
Male Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
CARCINOMA 4/48 26/44 7/45
|
Female Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
ADENOMA 2/46 8/42 19/45; CARCINOMA 1/46 28/42 13/45
|
