1,1,1,2-Tetrachloroethane: Target Organs and Levels of Evidence for TR-237
Carcinogenesis Studies of 1,1,1,2-Tetrachloroethane (CASRN 630-20-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
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1,1,1,2-Tetrachloroethane 630-20-6 | 12/16/1981 | Gavage R: 0,125,250, M: 0,250,500 MG/KG/50 PER GROUP | Gulf South Research Institute |
Levels of Evidence
Male Rats: Equivocal
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions | - Liver:
NEOPLASTIC NODULE 0/49 1/49 2/48 OR CARCINOMA 0/49 0/49 1/48 COMBINED 0/49 1/49 3/48
|
Non-Neoplastic Lesions | |
Female Rats: Negative
Male Mice: Positive
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions | - Liver:
ADENOMA 6/48 14/46 21/50
|
Non-Neoplastic Lesions | - LIVER: INFLAMMATION; NECROSIS; CYTOMEGALY; FATTY METAMORPHOSIS
|
Female Mice: Positive
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Liver:
ADENOMA 4/49 8/46 24/48 OR CARCINOMA 1/49 5/46 6/48 COMBINED 5/49 13/46 30/48
|
Non-Neoplastic Lesions | - LIVER: INFLAMMATION; NECROSIS; CYTOMEGALY; FATTY METAMORPHOSIS
|