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Ziram: Target Organs and Levels of Evidence for TR-238

Carcinogenesis Bioassay of Ziram (CASRN 137-30-4) in F344/N Rats and B6C3F1 Mice (Feed Study)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Ziram 137-30-4	12/16/1981	Dosed-Feed R: 0, 300, OR 600 PPM M: 0, 600, OR 1200 PPM	Southern Research Institute

Levels of Evidence

Male Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Thyroid Gland C-Cell: CARCINOMA 0/50 2/49 7/49

Female Rats: Negative

Male Mice: Negative

Female Mice: Equivocal

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 5/49 10/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 1/49 1/50 COMBINED 4/50 6/49 11/50