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Target Organs and Levels of Evidence for TR-243

Carcinogenesis Studies of Trichloroethylene (Without Epichlorohydrin) (CASRN 79-01-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
Peer Review Date Route/Exposure Levels Study Laboratory
09/22/1982 Gavage
R: 0,500,1000, M: 0,1000 MG/KG/50 PER GROUP
Papanicolaou Research Institute

Levels of Evidence

Male Rats: Inadequate Study
Female Rats: Negative
Male Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 8/48 30/50
Female Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 2/48 8/49; CARCINOMA 2/48 13/49