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Polybrominated biphenyl mixture (Firemaster FF-1): Target Organs and Levels of Evidence for TR-244

Toxicology and Carcinogenesis Studies of a Polybrominated Biphenyl Mixture (Firemaster FF-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Polybrominated biphenyl mixture (Firemaster FF-1) 67774-32-7	06/23/1981	Gavage 0,0.1,0.3,1.0,3.0,10.0 MG/KG/50 PER GROUP	National Institute of Env. Health Sciences

Levels of Evidence

Male Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: NEOPLASTIC NODULE 0/33 0/39 1/40 4/31 4/33 1/31; CARCINOMA 0/33 2/39 0/40 1/31 7/33 7/31; CHOLANGIOCARCINOMA 0/33 0/39 0/40 0/31 0/33 2/31

Female Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: NEOPLASTIC NODULE 0/20 2/21 0/21 2/11 5/19 8/20; CARCINOMA 0/20 0/21 0/21 0/11 3/19 7/20; CHOLANGIOCARCINOMA 0/20 0/21 0/21 0/11 0/19 7/20

Male Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: CARCINOMA 12/25 8/27 8/24 12/25 15/23 21/22

Female Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: CARCINOMA 0/13 0/19 2/15 2/11 3/17 7/8