Polybrominated biphenyl mixture (Firemaster FF-1): Target Organs and Levels of Evidence for TR-244
Toxicology and Carcinogenesis Studies of a Polybrominated Biphenyl Mixture (Firemaster FF-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
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Polybrominated biphenyl mixture (Firemaster FF-1) 67774-32-7 | 06/23/1981 | Gavage 0,0.1,0.3,1.0,3.0,10.0 MG/KG/50 PER GROUP | National Institute of Env. Health Sciences |
Levels of Evidence
Male Rats: Positive
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions | - Liver:
NEOPLASTIC NODULE 0/33 0/39 1/40 4/31 4/33 1/31; CARCINOMA 0/33 2/39 0/40 1/31 7/33 7/31; CHOLANGIOCARCINOMA 0/33 0/39 0/40 0/31 0/33 2/31
|
Female Rats: Positive
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Liver:
NEOPLASTIC NODULE 0/20 2/21 0/21 2/11 5/19 8/20; CARCINOMA 0/20 0/21 0/21 0/11 3/19 7/20; CHOLANGIOCARCINOMA 0/20 0/21 0/21 0/11 0/19 7/20
|
Male Mice: Positive
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Liver:
CARCINOMA 12/25 8/27 8/24 12/25 15/23 21/22
|
Female Mice: Positive
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Liver:
CARCINOMA 0/13 0/19 2/15 2/11 3/17 7/8
|