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4,4'-Methylenedianiline dihydrochloride: Target Organs and Levels of Evidence for TR-248

Carcinogenesis Studies of 4,4'-Methylenedianiline Dihydrochloride (CASRN 13552-44-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
4,4'-Methylenedianiline dihydrochloride 13552-44-8	06/16/1982	Dosed-Water 0,150,300 PPM/50 PER GROUP	T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Thyroid Gland Follicular Cell: CARCINOMA 0/49 0/47 7/48 Liver: NEOPLASTIC NODULE 1/50 12/50 25/50

Female Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Thyroid Gland Follicular Cell: ADENOMA 0/47 2/47 17/48 Thyroid Gland C-Cell: ADENOMA 0/47 3/47 6/48

Male Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Thyroid Gland Follicular Cell: ADENOMA 0/47 3/49 16/49 Liver: CARCINOMA 10/49 33/50 29/50 Adrenal Gland Medulla: PHEOCHROMOCYTOMA 2/48 12/49 14/49

Female Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Thyroid Gland Follicular Cell: ADENOMA 0/50 1/47 13/50 Liver: ADENOMA 3/50 9/50 12/50 Hematopoietic System: LYMPHOMA 13/50 28/50 29/50