4,4'-Methylenedianiline dihydrochloride: Target Organs and Levels of Evidence for TR-248
Carcinogenesis Studies of 4,4'-Methylenedianiline Dihydrochloride (CASRN 13552-44-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
4,4'-Methylenedianiline dihydrochloride
13552-44-8 | 06/16/1982 | Dosed-Water
0,150,300 PPM/50 PER GROUP | T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Thyroid Gland Follicular Cell:
CARCINOMA 0/49 0/47 7/48
- Liver:
NEOPLASTIC NODULE 1/50 12/50 25/50
|
Female Rats: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Thyroid Gland Follicular Cell:
ADENOMA 0/47 2/47 17/48
- Thyroid Gland C-Cell:
ADENOMA 0/47 3/47 6/48
|
Male Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Thyroid Gland Follicular Cell:
ADENOMA 0/47 3/49 16/49
- Liver:
CARCINOMA 10/49 33/50 29/50
- Adrenal Gland Medulla:
PHEOCHROMOCYTOMA 2/48 12/49 14/49
|
Female Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Thyroid Gland Follicular Cell:
ADENOMA 0/50 1/47 13/50
- Liver:
ADENOMA 3/50 9/50 12/50
- Hematopoietic System:
LYMPHOMA 13/50 28/50 29/50
|
