Target Organs and Levels of Evidence for TR-250
Toxicology and Carcinogenesis Studies of Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Benzyl acetate
140-11-4 |
11/02/1984 |
Gavage
R: 0,250,500, M: 0,500,1000 MG/KG/50 PER GROUP |
Southern Research Institute |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Pancreas Acinar Cell: ADENOMA 22/50 27/50 37/49
|
Female Rats: No Evidence
Male Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 0/50 5/49 13/50
- Forestomach: SQUAMOUS CELL PAPILLOMA 3/49 3/48 9/49 OR SQUAMOUS CELL CARCINOMA 1/49 1/48 2/49 COMBINED 4/49 4/48 11/49
|
Female Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 0/50 0/50 6/50
- Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/48
|
