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Target Organs and Levels of Evidence for TR-250

Toxicology and Carcinogenesis Studies of Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Benzyl acetate
140-11-4		 11/02/1984 Gavage
R: 0,250,500, M: 0,500,1000 MG/KG/50 PER GROUP		 Southern Research Institute

Levels of Evidence

Male Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Pancreas Acinar Cell: ADENOMA 22/50 27/50 37/49
Female Rats: No Evidence
Male Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 0/50 5/49 13/50
  • Forestomach: SQUAMOUS CELL PAPILLOMA 3/49 3/48 9/49 OR SQUAMOUS CELL CARCINOMA 1/49 1/48 2/49 COMBINED 4/49 4/48 11/49
Female Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 0/50 0/50 6/50
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/48