Target Organs and Levels of Evidence for TR-251
Toxicology and Carcinogenesis Studies of Commercial Grade 2,4 (80)- and 2,6 (20)- Toluene Diisocyanate (CASRN 26471-62-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
2,4- & 2,6-Toluene diisocyanate
26471-62-5 |
09/22/1982 |
Gavage
MR: 0,30,60, FR&FM: 0,60,120, MM: 0,120,240, MG/KG/50 PER GROUP |
Litton Bionetics, Inc. |
Levels of Evidence
Male Rats: Positive
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Subcutaneous Tissue: FIBROMA 3/50 3/50 9/50 OR FIBROSARCOMA 0/50 3/50 3/50 COMBINED 3/50 6/50 12/50
- Pancreas Acinar Cell: ADENOMA 1/47 3/47 7/49
|
Female Rats: Positive
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Subcutaneous Tissue: FIBROMA 0/50 1/50 3/50 OR FIBROSARCOMA 2/50 0/50 2/50 COMBINED 2/50 1/50 5/50
- Liver: NEOPLASTIC NODULE 3/50 8/50 8/48
- Pancreas Islet Cell: ADENOMA 0/50 6/49 2/47 CARCINOMA 0/50 1/49 0/47 COMBINED 0/50 7/49 2/47
- Mammary Gland: FIBROADENOMA 15/50 21/50 18/50
|
Male Mice: Negative
Female Mice: Positive
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Vascular System (Unspecified): HEMANGIOMA 0/50 1/50 2/50 OR HEMANGIOSARCOMA 0/50 0/50 3/50 COMBINED 0/50 1/50 5/50
- Liver: ADENOMA 2/50 3/50 12/50
|
