Diglycidyl resorcinol ether (DGRE): Target Organs and Levels of Evidence for TR-257
Toxicology and Carcinogenesis Studies of Diglycidyl Resorcinol Ether (Technical Grade) (CASRN 101-90-6) In F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Diglycidyl resorcinol ether (DGRE)
101-90-6 | 02/28/1983 | Gavage
R: 0,12,25,50, M: 0,50,100 PPM/50 PER GROUP | T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Forestomach:
SQUAMOUS CELL PAPILLOMA 0/50 17/50 6/49; SQUAMOUS CELL CARCINOMA 0/50 38/50 4/49
|
| Non-Neoplastic Lesions | - FORESTOMACH: HYPERKERATOSIS; HYPERPLASIA
|
Female Rats: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Forestomach:
SQUAMOUS CELL PAPILLOMA 0/49 7/50 1/50; SQUAMOUS CELL CARCINOMA 0/49 34/50 3/50
|
| Non-Neoplastic Lesions | - FORESTOMACH: HYPERKERATOSIS; HYPERPLASIA
|
Male Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Forestomach:
SQUAMOUS CELL PAPILLOMA 0/47 4/49 10/50; SQUAMOUS CELL CARCINOMA 0/47 14/49 25/50
|
| Non-Neoplastic Lesions | - FORESTOMACH: HYPERKERATOSIS; HYPERPLASIA
|
Female Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Forestomach:
SQUAMOUS CELL PAPILLOMA 0/47 5/49 10/49; SQUAMOUS CELL CARCINOMA 0/47 12/49 23/49
|
| Non-Neoplastic Lesions | - FORESTOMACH: HYPERKERATOSIS; HYPERPLASIA
|
