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Target Organs and Levels of Evidence for TR-257

Toxicology and Carcinogenesis Studies of Diglycidyl Resorcinol Ether (Technical Grade) (CASRN 101-90-6) In F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Diglycidyl resorcinol ether (DGRE)
101-90-6		 02/28/1983 Gavage
R: 0,12,25,50, M: 0,50,100 PPM/50 PER GROUP		 T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 17/50 6/49; SQUAMOUS CELL CARCINOMA 0/50 38/50 4/49
Non-Neoplastic Lesions
  • FORESTOMACH: HYPERKERATOSIS; HYPERPLASIA
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/49 7/50 1/50; SQUAMOUS CELL CARCINOMA 0/49 34/50 3/50
Non-Neoplastic Lesions
  • FORESTOMACH: HYPERKERATOSIS; HYPERPLASIA
Male Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/47 4/49 10/50; SQUAMOUS CELL CARCINOMA 0/47 14/49 25/50
Non-Neoplastic Lesions
  • FORESTOMACH: HYPERKERATOSIS; HYPERPLASIA
Female Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/47 5/49 10/49; SQUAMOUS CELL CARCINOMA 0/47 12/49 23/49
Non-Neoplastic Lesions
  • FORESTOMACH: HYPERKERATOSIS; HYPERPLASIA