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Target Organs and Levels of Evidence for TR-259

Carcinogenesis Studies of Ethyl Acrylate (CASRN 140-88-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Ethyl acrylate 140-88-5	02/28/1983	Gavage 0,100,200 MG/KG/50 PER GROUP	Southern Research Institute

Levels of Evidence

Male Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 15/50 29/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 12/50 COMBINED 1/50 18/50 36/50

Female Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 6/50 9/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 1/50 6/50 11/50

Male Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Forestomach: SQUAMOUS CELL PAPILLOMA 0/48 4/47 9/50 OR SQUAMOUS CELL CARCINOMA 0/48 2/47 5/50 COMBINED 0/48 5/47 12/50

Female Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 4/49 5/48 OR SQUAMOUS CELL CARCINOMA 0/50 1/49 2/48 COMBINED 1/50 5/49 7/48