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Target Organs and Levels of Evidence for TR-259

Carcinogenesis Studies of Ethyl Acrylate (CASRN 140-88-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Ethyl acrylate
140-88-5		 02/28/1983 Gavage
0,100,200 MG/KG/50 PER GROUP		 Southern Research Institute

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 15/50 29/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 12/50 COMBINED 1/50 18/50 36/50
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 6/50 9/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 1/50 6/50 11/50
Male Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/48 4/47 9/50 OR SQUAMOUS CELL CARCINOMA 0/48 2/47 5/50 COMBINED 0/48 5/47 12/50
Female Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 4/49 5/48 OR SQUAMOUS CELL CARCINOMA 0/50 1/49 2/48 COMBINED 1/50 5/49 7/48