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Target Organs and Levels of Evidence for TR-263

Toxicology and Carcinogenesis Studies of 1,2-Dichloropropane (Propylene Dichloride) (CASRN 78-87-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
1,2-Dichloropropane (propylene dichloride) 78-87-5	06/29/1983	Gavage FR&M: 0,125,250, MR: 0,62,125 MG/KG/50 PER GROUP	T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: No Evidence

Female Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Mammary Gland: ADENOCARCINOMA 1/50 2/50 5/50

Male Mice: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: ADENOMA 7/50 10/50 17/50

Female Mice: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: ADENOMA 1/50 5/50 5/50