Target Organs and Levels of Evidence for TR-263
Toxicology and Carcinogenesis Studies of 1,2-Dichloropropane (Propylene Dichloride) (CASRN 78-87-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
1,2-Dichloropropane (propylene dichloride)
78-87-5 |
06/29/1983 |
Gavage
FR&M: 0,125,250, MR: 0,62,125 MG/KG/50 PER GROUP |
T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: No Evidence
Female Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Mammary Gland: ADENOCARCINOMA 1/50 2/50 5/50
|
Male Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 7/50 10/50 17/50
|
Female Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 1/50 5/50 5/50
|
