Target Organs and Levels of Evidence for TR-267
Toxicology and Carcinogenesis Studies of Propylene Oxide (CASRN 75-56-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
1,2-Propylene oxide 75-56-9 |
06/29/1983 |
Inhalation 0,200,400 PPM/50 PER GROUP |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Nasal Cavity: ADENOMA 0/50 0/50 2/50
|
Non-Neoplastic Lesions |
- NASAL CAVITY: INFLAMMATION, SUPPURATIVE; HYPERPLASIA, EPITHELIAL; METAPLASIA, SQUAMOUS
|
Female Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Nasal Cavity: ADENOMA 0/50 0/50 3/50
|
Non-Neoplastic Lesions |
- NASAL CAVITY: INFLAMMATION, SUPPURATIVE; HYPERPLASIA, EPITHELIAL; METAPLASIA, SQUAMOUS
|
Male Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Vascular System (Nasal Cavity): HEMANGIOMA 0/50 0/50 5/50; HEMANGIOSARCOMA 0/50 0/50 5/50
|
Non-Neoplastic Lesions |
- NASAL CAVITY: INFLAMMATION, SUPPURATIVE
|
Female Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Vascular System (Nasal Cavity): HEMANGIOMA 0/50 0/50 3/50; HEMANGIOSARCOMA 0/50 0/50 2/50
|
Non-Neoplastic Lesions |
- NASAL CAVITY: INFLAMMATION, SUPPURATIVE
|