Target Organs and Levels of Evidence for TR-269
Toxicology and Carcinogenesis Studies of Telone® (Technical-Grade 1,3-Dichloropropane [CASRN 542-75-6] Containing 1.0 Epichlorohydrin as a Stabilizer) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
1,3-Dichloropropene (Telone II)
542-75-6 |
07/27/1984 |
Gavage
R: 0,25,50, M: 0,50,100 MG/KG/50 PER GROUP |
Frederick Cancer Research Facility |
Levels of Evidence
Male Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 1/52 1/52 9/52; SQUAMOUS CELL CARCINOMA 0/52 0/52 4/52
- Liver: NEOPLASTIC NODULE 1/52 6/52 7/52
|
| Non-Neoplastic Lesions |
- FORESTOMACH: HYPERPLASIA, EPITHELIAL; HYPERPLASIA, BASAL CELL
|
Female Rats: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 0/52 2/52 3/52
|
| Non-Neoplastic Lesions |
- FORESTOMACH: HYPERPLASIA, EPITHELIAL; HYPERPLASIA, BASAL CELL
|
Male Mice: Inadequate Study
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- FORESTOMACH: HYPERPLASIA, EPITHELIAL
- URINARY BLADDER: HYPERPLASIA, EPITHELIAL
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Urinary Bladder: TRANSITIONAL CELL CARCINOMA 0/50 8/50 21/48
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 3/50 8/50
- Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 1/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 0/50 1/50 4/50
|
| Non-Neoplastic Lesions |
- FORESTOMACH: HYPERPLASIA, EPITHELIAL
- URINARY BLADDER: HYPERPLASIA, EPITHELIAL
|
