HC Blue 1: Target Organs and Levels of Evidence for TR-271
Toxicology and Carcinogenesis Studies of HC Blue No. 1 (CASRN 2784-94-3) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
HC blue 1
2784-94-3 | 03/23/1984 | Dosed-Feed
R&MM: 0,1500,3000, FM: 0,3000,6000 PPM/50 PER GROUP | Southern Research Institute |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
NEOPLASTIC NODULE 0/49 0/50 3/50; CARCINOMA 1/49 0/50 6/50
|
Female Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 2/49 3/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/49 4/50 COMBINED 1/50 3/49 7/50
|
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
CARCINOMA 11/50 20/50 30/50
|
| May Have Been Related | - Thyroid Gland Follicular Cell:
ADENOMA 0/47 0/49 5/50
|
Female Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
CARCINOMA 1/50 24/48 47/49
|
