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tris(2-Ethylhexyl)phosphate: Target Organs and Levels of Evidence for TR-274

Toxicology and Carcinogenesis Studies of Tris(2-ethylhexyl)phosphate (CASRN 78-42-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
tris(2-Ethylhexyl)phosphate 78-42-2	10/28/1983	Gavage MR: 0,2000,4000, FR: 0,1000,2000, M: 0,500,1000 MG/KG/50 PER GROUP	Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Adrenal Gland Medulla: PHEOCHROMOCYTOMA 2/50 9/50 12/50

Female Rats: No Evidence

Male Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL

Female Mice: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: CARCINOMA 0/48 4/50 7/50
Non-Neoplastic Lesions	THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL