Skip to Main Navigation
Skip to Page Content
COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/8135

tris(2-Ethylhexyl)phosphate: Target Organs and Levels of Evidence for TR-274

Toxicology and Carcinogenesis Studies of Tris(2-ethylhexyl)phosphate (CASRN 78-42-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN		Peer Review DateRoute/Exposure LevelsStudy Laboratory
tris(2-Ethylhexyl)phosphate
78-42-2		10/28/1983Gavage
MR: 0,2000,4000, FR: 0,1000,2000, M: 0,500,1000 MG/KG/50 PER GROUP		Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 2/50 9/50 12/50
Female Rats: No Evidence
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 0/48 4/50 7/50
Non-Neoplastic Lesions
  • THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL