tris(2-Ethylhexyl)phosphate: Target Organs and Levels of Evidence for TR-274
Toxicology and Carcinogenesis Studies of Tris(2-ethylhexyl)phosphate (CASRN 78-42-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
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tris(2-Ethylhexyl)phosphate 78-42-2 | 10/28/1983 | Gavage MR: 0,2000,4000, FR: 0,1000,2000, M: 0,500,1000 MG/KG/50 PER GROUP | Litton Bionetics, Inc. |
Levels of Evidence
Male Rats: Equivocal Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Adrenal Gland Medulla:
PHEOCHROMOCYTOMA 2/50 9/50 12/50
|
Female Rats: No Evidence
Male Mice: No Evidence
Type | Organ/Tissue (Lesion) |
---|
Non-Neoplastic Lesions | - THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL
|
Female Mice: Some Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Liver:
CARCINOMA 0/48 4/50 7/50
|
Non-Neoplastic Lesions | - THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL
|