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Target Organs and Levels of Evidence for TR-284

Toxicology and Carcinogenesis Studies of Diallylphthalate (CASRN 131-17-9) in F344/N Rats (Gavage Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Diallyl phthalate 131-17-9	03/23/1984	Gavage 0,50,100 MG/KG/50 PER GROUP	Litton Bionetics, Inc.

Levels of Evidence

Male Rats: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	LIVER: FIBROSIS, PERIPORTAL; PIGMENTATION; HYPERPLASIA, BILE DUCT

Female Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Hematopoietic System: LEUKEMIA 15/50 15/43 25/49
Non-Neoplastic Lesions	LIVER: FIBROSIS, PERIPORTAL; PIGMENTATION; HYPERPLASIA, BILE DUCT