C.I. Basic Red 9 Monohydrochloride: Target Organs and Levels of Evidence for TR-285
Toxicology and Carcinogenesis Studies of C.I. Basic Red 9 Monohydrochloride (Pararosaniline) (CASRN 569-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
C.I. Basic red 9 monohydrochloride
569-61-9 | 03/29/1985 | Dosed-Feed
MR: 0, 1000, OR 2000 PPM -- FR AND M&F MICE 0, 500, OR 1000 PPM; 50/SEX/SPECIES | T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Subcutaneous Tissue:
FIBROMA 2/50 20/50 16/50
- Skin:
TRICHOEPITHELIOMA 0/50 0/50 7/50; SEBACEOUS ADENOMA 0/50 0/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 10/50
- Thyroid Gland Follicular Cell:
ADENOMA 0/49 0/46 9/44 OR CARCINOMA 0/49 5/46 18/44
- Zymbal Gland:
CARCINOMA 1/50 1/50 13/50
- Liver:
CARCINOMA 0/50 2/50 8/50
|
Female Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Subcutaneous Tissue:
FIBROMA 0/50 15/50 10/50
- Thyroid Gland Follicular Cell:
ADENOMA 0/47 0/48 4/50 OR CARCINOMA 0/47 2/48 2/50 COMBINED 0/47 2/48 6/50
- Zymbal Gland:
CARCINOMA 0/50 2/50 7/50
|
| May Have Been Related | - Mammary Gland:
ADENOMA 0/50 3/50 1/50, FIBROADENOMA 22/50 31/50 29/50, OR ADENOCARCINOMA 2/50 2/50 5/50 COMBINED 23/50 32/50 32/50
|
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
CARCINOMA 10/50 20/50 27/50
|
Female Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
CARCINOMA 3/49 19/50 37/49
- Adrenal Gland Medulla:
PHEOCHROMOCYTOMA 1/48 7/47 7/45 OR MALIGNANT PHEOCHROMOCYTOMA 0/48 1/47 1/45 COMBINED 1/48 8/47 8/45
|
| May Have Been Related | - Hematopoietic System:
LYMPHOMA 17/50 24/50 25/50
|
