1,3-Butadiene: Target Organs and Levels of Evidence for TR-288
Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CASRN 106-99-0) in B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
1,3-Butadiene
106-99-0 | 10/28/1983 | Inhalation
0,625,1250 PPM/50 PER GROUP | Battelle Northwest Laboratory |
Levels of Evidence
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Hematopoietic System:
LYMPHOMA 0/50 23/50 29/50
- Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 12/49 11/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 2/49 5/49
- Forestomach:
PAPILLOMA 0/49 5/40 0/44
- Vascular System (Heart):
HEMANGIOSARCOMA 0/50 16/49 7/49
|
| May Have Been Related | - Zymbal Gland:
CARCINOMA 0/50 0/50 2/50
- Preputial Gland:
SQUAMOUS CELL CARCINOMA 0/50 3/50 1/50
- Brain:
GLIOMA 0/50 2/48 1/49
|
| Non-Neoplastic Lesions | - NASAL CAVITY: INFLAMMATION, CHRONIC; FIBROSIS; METAPLASIA, CARTILAGINOUS; METAPLASIA, OSSEOUS
- TESTES: ATROPHY
|
Female Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Hematopoietic System:
LYMPHOMA 1/50 10/49 10/49
- Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 9/48 20/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 6/48 8/49
- Forestomach:
PAPILLOMA 0/49 4/42 10/49
- Liver:
ADENOMA 0/50 1/47 4/49 OR CARCINOMA 0/50 1/47 1/49 COMBINED 0/50 2/47 5/49
- Mammary Gland:
ACINAR CELL CARCINOMA 0/50 2/49 6/49
- Ovary:
GRANULOSA CELL TUMOR 0/49 6/45 12/48
- Vascular System (Heart):
HEMANGIOSARCOMA 0/50 11/48 18/49
|
| Non-Neoplastic Lesions | - NASAL CAVITY: INFLAMMATION, CHRONIC; FIBROSIS; METAPLASIA, CARTILAGINOUS; METAPLASIA, OSSEOUS
- OVARY: ATROPHY
|
