Target Organs and Levels of Evidence for TR-289
Toxicology and Carcinogenesis Studies of Benzene (CASRN 71-43-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Benzene
71-43-2 |
07/27/1984 |
Gavage
FR&M: 0,25,50,100, MR: 0,50,100,200 MG/KG/50 PER GROUP |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Zymbal Gland: CARCINOMA 2/32 6/46 10/42
- Oral Cavity: SQUAMOUS CELL PAPILLOMA 1/50 6/50 11/50 13/50 OR SQUAMOUS CELL CARCINOMA 0/50 3/50 5/50 7/50 COMBINED 1/50 9/50 16/50 19/50
- Skin: SQUAMOUS CELL PAPILLOMA 0/50 2/50 1/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 5/50 3/50 8/50
|
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Zymbal Gland: CARCINOMA 0/45 5/40 5/44 14/46
- Oral Cavity: SQUAMOUS CELL PAPILLOMA 1/50 4/50 8/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 4/50 5/50 COMBINED 1/50 5/50 12/50 9/50
|
Male Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Zymbal Gland: SQUAMOUS CELL CARCINOMA 0/43 1/34 4/40 21/39
- Hematopoietic System: LYMPHOMA 4/49 10/48 10/50 15/49
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 6/49 6/48 8/50 12/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 5/49 11/48 12/50 14/49 COMBINED 10/49 16/48 19/50 21/49
- Harderian Gland: ADENOMA 0/49 9/46 13/49 11/48
- Preputial Gland: SQUAMOUS CELL CARCINOMA 0/21 3/28 18/29 28/35
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Zymbal Gland: SQUAMOUS CELL CARCINOMA 0/43 0/32 1/37 3/31
- Hematopoietic System: LYMPHOMA 15/49 25/45 26/50 22/49
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 2/42 5/50 9/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 3/42 6/50 6/49 COMBINED 4/49 5/42 10/50 13/49
- Ovary: BENIGN MIXED TUMORS 0/47 1/44 12/49 7/48; GRANULOSA CELL TUMOR 1/47 1/44 6/49 7/48
- Mammary Gland: CARCINOMA 0/49 2/45 5/50 10/49; CARCINOSARCOMA 0/49 0/45 1/50 4/49
|
