C.I. Disperse Blue 1: Target Organs and Levels of Evidence for TR-299
Toxicology and Carcinogenesis Studies of C.I. Disperse Blue 1 (A commercial dye containing approximately 50% 1,4,5,8-tetraaminoanthraquinone, and 20% water) (CASRN 2475-45-8) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
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C.I. Disperse blue 1 2475-45-8 | 03/29/1985 | Dosed-Feed R: 0,12500,2500,5000, M: 0,600,1200,2500 PPM/50 PER GROUP | Southern Research Institute |
Levels of Evidence
Male Rats: Clear Evidence
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions | - Urinary Bladder:
TRANSITIONAL CELL PAPILLOMA 0/49 0/50 8/50 4/49 OR TRANSITIONAL CELL CARCINOMA 0/49 0/50 4/50 8/49 COMBINED 0/49 0/50 10/50 11/49; LEIOMYOMA 0/49 0/50 7/50 41/49 OR LEIOMYOSARCOMA 0/49 0/50 6/50 41/49 COMBINED 0/49 0/50 7/50 41/49; SQUAMOUS CELL PAPILLOMA 0/49 0/50 1/50 3/49 OR SQUAMOUS CELL CARCINOMA 0/49 0/50 1/50 1/49 COMBINED 0/49 0/50 2/50 4/49
|
May Have Been Related | - Pancreas Islet Cell:
ADENOMA 1/49 0/50 4/50 2/50 OR CARCINOMA 0/49 2/50 1/50 1/50 COMBINED 1/49 2/50 5/50 3/50
|
Non-Neoplastic Lesions | |
Female Rats: Clear Evidence
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions | - Urinary Bladder:
TRANSITIONAL CELL PAPILLOMA 0/48 0/50 9/50 15/48 OR TRANSITIONAL CELL CARCINOMA 0/48 0/50 10/50 13/48 COMBINED 0/48 0/50 15/50 21/48; LEIOMYOMA 0/48 0/50 1/50 4/48 OR LEIOMYOSARCOMA 0/48 0/50 2/50 23/48 COMBINED 0/48 0/50 3/50 26/48; SQUAMOUS CELL PAPILLOMA 0/48 0/50 1/50 7/48 OR SQUAMOUS CELL CARCINOMA 0/48 0/50 1/50 4/48 COMBINED 0/48 0/50 1/50 11/48
|
Non-Neoplastic Lesions | |
Male Mice: Equivocal Evidence
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions | - Liver:
ADENOMA 3/50 9/50 10/50 9/50 OR CARCINOMA 6/50 15/50 13/50 8/50 COMBINED 9/50 21/50 20/50 16/50
- Lung:
ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 3/49 5/50 5/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 6/49 1/50 6/50 COMBINED 4/50 9/49 5/50 11/50
|
Female Mice: No Evidence