Target Organs and Levels of Evidence for TR-300
Toxicology and Carcinogenesis Studies of 3-Chloro-2-methylpropene (Technical grade containing 5% Dimethylvinyl chloride) (CASRN 563-47-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
3-Chloro-2-methylpropene
563-47-3 |
11/02/1984 |
Gavage
R: 0,75,150, M: 0,100,200 MG/KG/50 PER GROUP |
Litton Bionetics, Inc. |
Levels of Evidence
Male Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 5/50 30/48; SQUAMOUS CELL CARCINOMA 0/50 0/50 2/48
|
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 1/50 10/50
|
Male Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 3/49 19/49 30/49; SQUAMOUS CELL CARCINOMA 0/49 5/49 7/49
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 15/48 29/44; SQUAMOUS CELL CARCINOMA 0/50 1/48 2/44
|
