Target Organs and Levels of Evidence for TR-304
Toxicology and Carcinogenesis Studies of Chlorendic Acid (CASRN 115-28-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Chlorendic acid
115-28-6 |
08/14/1985 |
Dosed-Feed
0,620,1250 PPM/50 PER GROUP |
Hazleton, Vienna |
Levels of Evidence
Male Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: NEOPLASTIC NODULE 2/50 21/50 23/50
- Pancreas Acinar Cell: ADENOMA 0/49 4/50 6/50
|
| May Have Been Related |
- Lung: ADENOMA 0/50 3/50 5/50
- Preputial Gland: CARCINOMA 1/50 8/50 4/50
|
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: NEOPLASTIC NODULE 1/50 3/49 11/50; CARCINOMA 0/50 3/49 5/50
|
Male Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 5/50 9/49 10/50; CARCINOMA 9/50 17/49 20/50
|
Female Mice: No Evidence
