Chlorendic acid: Target Organs and Levels of Evidence for TR-304
Toxicology and Carcinogenesis Studies of Chlorendic Acid (CASRN 115-28-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Chlorendic acid
115-28-6 | 08/14/1985 | Dosed-Feed
0,620,1250 PPM/50 PER GROUP | Hazleton, Vienna |
Levels of Evidence
Male Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
NEOPLASTIC NODULE 2/50 21/50 23/50
- Pancreas Acinar Cell:
ADENOMA 0/49 4/50 6/50
|
| May Have Been Related | - Lung:
ADENOMA 0/50 3/50 5/50
- Preputial Gland:
CARCINOMA 1/50 8/50 4/50
|
Female Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
NEOPLASTIC NODULE 1/50 3/49 11/50; CARCINOMA 0/50 3/49 5/50
|
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
ADENOMA 5/50 9/49 10/50; CARCINOMA 9/50 17/49 20/50
|
Female Mice: No Evidence
