Chlorinated paraffins: C23, 43% chlorine: Target Organs and Levels of Evidence for TR-305
Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C23, 43Chlorine) (CASRN 108171-27-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Chlorinated paraffins: C23, 43% chlorine
108171-27-3 | 08/14/1985 | Gavage
FR: 0,100,300,900, MR: 0,1875,3750, M: 0,2500,5000 MG/KG/50 PER GROUP | Southern Research Institute |
Levels of Evidence
Male Rats: No Evidence
Female Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Adrenal Gland Medulla:
PHEOCHROMOCYTOMA 1/50 4/50 6/50 7/50
|
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Hematopoietic System:
LYMPHOMA 6/50 12/50 16/50
|
Female Mice: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
ADENOMA 3/50 2/49 7/50 OR CARCINOMA 1/50 1/49 6/50 COMBINED 4/50 3/49 10/50
|
