Target Organs and Levels of Evidence for TR-305
Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C23, 43Chlorine) (CASRN 108171-27-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Chlorinated paraffins: C23, 43% chlorine
108171-27-3 |
08/14/1985 |
Gavage
FR: 0,100,300,900, MR: 0,1875,3750, M: 0,2500,5000 MG/KG/50 PER GROUP |
Southern Research Institute |
Levels of Evidence
Male Rats: No Evidence
Female Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Adrenal Gland Medulla: PHEOCHROMOCYTOMA 1/50 4/50 6/50 7/50
|
Male Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Hematopoietic System: LYMPHOMA 6/50 12/50 16/50
|
Female Mice: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 3/50 2/49 7/50 OR CARCINOMA 1/50 1/49 6/50 COMBINED 4/50 3/49 10/50
|
