Target Organs and Levels of Evidence for TR-308
Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C12, 60% Chlorine) (CASRN 108171-26-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Chlorinated paraffins: C12, 60% chlorine
108171-26-2 |
08/14/1985 |
Gavage
R: 0,312,625, M: 0,125,250 MG/KG/50 PER GROUP |
Southern Research Institute |
Levels of Evidence
Male Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: NEOPLASTIC NODULE 0/50 10/50 16/48; CARCINOMA 0/50 3/50 2/48
- Kidney Tubular Cell: ADENOMA 0/50 7/50 3/49 ADENOCARCINOMA 0/50 2/50 0/49 COMBINED 0/50 9/50 3/49
|
| May Have Been Related |
- Hematopoietic System: LEUKEMIA 7/50 12/50 14/50
|
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: NEOPLASTIC NODULE 0/50 4/50 7/50; CARCINOMA 0/50 1/50 1/50
- Thyroid Gland Follicular Cell: ADENOMA 0/50 6/50 3/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 6/50 6/50
|
Male Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 11/50 20/50 29/50 OR CARCINOMA 11/50 15/50 17/50 COMBINED 2/50 34/50 38/50
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 0/50 18/50 22/50 OR CARCINOMA 3/50 4/50 9/50 COMBINED 3/50 22/50 28/50
- Thyroid Gland Follicular Cell: ADENOMA 8/50 12/49 18/49 OR CARCINOMA 0/50 0/49 2/49 COMBINED 8/50 12/49 15/49
|
