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Target Organs and Levels of Evidence for TR-311

Toxicology and Carcinogenesis Studies of Tetrachloroethylene (Perchloroethylene) (CASRN 127-18-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Tetrachloroethylene 127-18-4	08/14/1985	Inhalation R: 0,200,400, M: 0,100,200 PPM/50 PER GROUP	Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Clear Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Hematopoietic System: LEUKEMIA 28/50 37/50 37/50 Kidney Tubular Cell: ADENOMA 1/49 3/49 2/50 OR ADENOCARCINOMA 0/49 0/49 2/50 COMBINED 1/49 3/49 4/50

Female Rats: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Hematopoietic System: LEUKEMIA 18/50 30/50 29/50

Male Mice: Clear Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: ADENOMA 11/49 8/49 18/50; CARCINOMA 7/49 25/49 26/50

Female Mice: Clear Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: CARCINOMA 1/48 13/50 36/50