Target Organs and Levels of Evidence for TR-311
Toxicology and Carcinogenesis Studies of Tetrachloroethylene (Perchloroethylene) (CASRN 127-18-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Tetrachloroethylene 127-18-4 |
08/14/1985 |
Inhalation R: 0,200,400, M: 0,100,200 PPM/50 PER GROUP |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Hematopoietic System: LEUKEMIA 28/50 37/50 37/50
- Kidney Tubular Cell: ADENOMA 1/49 3/49 2/50 OR ADENOCARCINOMA 0/49 0/49 2/50 COMBINED 1/49 3/49 4/50
|
Female Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Hematopoietic System: LEUKEMIA 18/50 30/50 29/50
|
Male Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 11/49 8/49 18/50; CARCINOMA 7/49 25/49 26/50
|
Female Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: CARCINOMA 1/48 13/50 36/50
|