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Target Organs and Levels of Evidence for TR-311

Toxicology and Carcinogenesis Studies of Tetrachloroethylene (Perchloroethylene) (CASRN 127-18-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Tetrachloroethylene
127-18-4		 08/14/1985 Inhalation
R: 0,200,400, M: 0,100,200 PPM/50 PER GROUP		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: LEUKEMIA 28/50 37/50 37/50
  • Kidney Tubular Cell: ADENOMA 1/49 3/49 2/50 OR ADENOCARCINOMA 0/49 0/49 2/50 COMBINED 1/49 3/49 4/50
Female Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: LEUKEMIA 18/50 30/50 29/50
Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 11/49 8/49 18/50; CARCINOMA 7/49 25/49 26/50
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 1/48 13/50 36/50