Tetrachloroethylene: Target Organs and Levels of Evidence for TR-311
Toxicology and Carcinogenesis Studies of Tetrachloroethylene (Perchloroethylene) (CASRN 127-18-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Tetrachloroethylene
127-18-4 | 08/14/1985 | Inhalation
R: 0,200,400, M: 0,100,200 PPM/50 PER GROUP | Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Hematopoietic System:
LEUKEMIA 28/50 37/50 37/50
- Kidney Tubular Cell:
ADENOMA 1/49 3/49 2/50 OR ADENOCARCINOMA 0/49 0/49 2/50 COMBINED 1/49 3/49 4/50
|
Female Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Hematopoietic System:
LEUKEMIA 18/50 30/50 29/50
|
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
ADENOMA 11/49 8/49 18/50; CARCINOMA 7/49 25/49 26/50
|
Female Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
CARCINOMA 1/48 13/50 36/50
|
