Target Organs and Levels of Evidence for TR-316
Toxicology and Carcinogenesis Studies of Dimethylvinyl Chloride (1-Chloro-2-Methylpropene) (CASRN 513-37-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Dimethylvinyl chloride (DMVC)
513-37-1 |
12/09/1985 |
Gavage
0,100,200 MG/KG/50 PER GROUP |
Litton Bionetics, Inc. |
Levels of Evidence
Male Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Nasal Cavity: ADENOCARCINOMA 0/47 8/46 4/32; CARCINOMA 0/47 12/46 24/32; SQUAMOUS CELL CARCINOMA 0/47 3/46 0/32
- Oral Cavity: SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 2/50 COMBINED 0/50 5/50 4/50
- Esophagus: SQUAMOUS CELL PAPILLOMA 0/50 2/50 3/49 OR SQUAMOUS CELL CARCINOMA 0/50 4/50 1/49 COMBINED 0/50 6/50 4/49
- Forestomach: SQUAMOUS CELL PAPILLOMA 0/49 7/50 0/50; SQUAMOUS CELL CARCINOMA 0/49 7/50 0/50
|
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Nasal Cavity: ADENOCARCINOMA 0/50 3/49 6/41; CARCINOMA 0/50 11/49 28/41; SQUAMOUS CELL CARCINOMA 0/50 2/49 2/41
- Oral Cavity: SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50 OR SQUAMOUS CELL CARCINOMA 0/50 2/50 1/50 COMBINED 0/50 2/50 5/50
- Esophagus: SQUAMOUS CELL CARCINOMA 0/49 3/50 1/49
- Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 4/50 1/49 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 1/49 COMBINED 1/50 9/50 2/49
|
Male Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 1/48 3/47 8/44; SQUAMOUS CELL CARCINOMA 0/48 42/47 35/44
- Preputial Gland: SQUAMOUS CELL CARCINOMA 1/48 3/47 16/44
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL CARCINOMA 0/50 40/47 36/43
|
