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Target Organs and Levels of Evidence for TR-319

Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene (CASRN 106-46-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
1,4-Dichlorobenzene (p-dichlorobenzene) 106-46-7	03/26/1986	Gavage MR: 0,150,300 MG/KG, FR: 0,300,600 MG/KG, M: 0,300,600 MG/KG/50 PER GROUP	Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Clear Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Kidney Tubular Cell: ADENOCARCINOMA 1/50 3/50 7/50
Non-Neoplastic Lesions	KIDNEY: INCREASED SEVERITY OF NEPHROPATHY; HYPERPLASIA, EPITHELIAL, PELVIS; MINERALIZATION, TUBULE; HYPERPLASIA, EPITHELIAL, TUBULE

Female Rats: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	KIDNEY: NEPHROPATHY

Male Mice: Clear Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: ADENOMA 5/50 13/49 16/50; CARCINOMA 14/50 11/49 32/50
May Have Been Related	Adrenal Gland Medulla: PHEOCHROMOCYTOMA 0/47 2/48 4/49
Non-Neoplastic Lesions	LIVER: CYTOMEGALY; KARYOMEGALY; DEGENERATION; NECROSIS THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL ADRENAL GLAND: HYPERPLASIA, MEDULLA; HYPERPLASIA, CAPSULE

Female Mice: Clear Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: ADENOMA 10/50 6/48 21/50; CARCINOMA 5/50 5/48 19/50
Non-Neoplastic Lesions	LIVER: CYTOMEGALY; KARYOMEGALY; DEGENERATION; NECROSIS