Target Organs and Levels of Evidence for TR-319
Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene (CASRN 106-46-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
1,4-Dichlorobenzene (p-dichlorobenzene) 106-46-7 |
03/26/1986 |
Gavage MR: 0,150,300 MG/KG, FR: 0,300,600 MG/KG, M: 0,300,600 MG/KG/50 PER GROUP |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney Tubular Cell: ADENOCARCINOMA 1/50 3/50 7/50
|
Non-Neoplastic Lesions |
- KIDNEY: INCREASED SEVERITY OF NEPHROPATHY; HYPERPLASIA, EPITHELIAL, PELVIS; MINERALIZATION, TUBULE; HYPERPLASIA, EPITHELIAL, TUBULE
|
Female Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
|
Male Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 5/50 13/49 16/50; CARCINOMA 14/50 11/49 32/50
|
May Have Been Related |
- Adrenal Gland Medulla: PHEOCHROMOCYTOMA 0/47 2/48 4/49
|
Non-Neoplastic Lesions |
- LIVER: CYTOMEGALY; KARYOMEGALY; DEGENERATION; NECROSIS
- THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL
- ADRENAL GLAND: HYPERPLASIA, MEDULLA; HYPERPLASIA, CAPSULE
|
Female Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 10/50 6/48 21/50; CARCINOMA 5/50 5/48 19/50
|
Non-Neoplastic Lesions |
- LIVER: CYTOMEGALY; KARYOMEGALY; DEGENERATION; NECROSIS
|