1,4-Dichlorobenzene (p-dichlorobenzene): Target Organs and Levels of Evidence for TR-319
Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene (CASRN 106-46-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
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1,4-Dichlorobenzene (p-dichlorobenzene) 106-46-7 | 03/26/1986 | Gavage MR: 0,150,300 MG/KG, FR: 0,300,600 MG/KG, M: 0,300,600 MG/KG/50 PER GROUP | Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions | - Kidney Tubular Cell:
ADENOCARCINOMA 1/50 3/50 7/50
|
Non-Neoplastic Lesions | - KIDNEY: INCREASED SEVERITY OF NEPHROPATHY; HYPERPLASIA, EPITHELIAL, PELVIS; MINERALIZATION, TUBULE; HYPERPLASIA, EPITHELIAL, TUBULE
|
Female Rats: No Evidence
Type | Organ/Tissue (Lesion) |
---|
Non-Neoplastic Lesions | |
Male Mice: Clear Evidence
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions | - Liver:
ADENOMA 5/50 13/49 16/50; CARCINOMA 14/50 11/49 32/50
|
May Have Been Related | - Adrenal Gland Medulla:
PHEOCHROMOCYTOMA 0/47 2/48 4/49
|
Non-Neoplastic Lesions | - LIVER: CYTOMEGALY; KARYOMEGALY; DEGENERATION; NECROSIS
- THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL
- ADRENAL GLAND: HYPERPLASIA, MEDULLA; HYPERPLASIA, CAPSULE
|
Female Mice: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Liver:
ADENOMA 10/50 6/48 21/50; CARCINOMA 5/50 5/48 19/50
|
Non-Neoplastic Lesions | - LIVER: CYTOMEGALY; KARYOMEGALY; DEGENERATION; NECROSIS
|