Bromodichloromethane: Target Organs and Levels of Evidence for TR-321
Toxicology and Carcinogenesis Studies of Bromodichloromethane (CASRN 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Bromodichloromethane
75-27-4 | 08/19/1986 | Gavage
R: 0,50,100 MM:0,25,50 FM: 0,75,150 MG/KG/50 PER GROUP | T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Kidney Tubular Cell:
ADENOMA 0/50 1/50 3/50; ADENOCARCINOMA 0/50 0/50 10/50; COMBINED 0/50, 1/50, 13/50
- Large Intestines:
ADENOMATOUS POLYP 0/50 3/50 33/50; ADENOCARCINOMA 0/50 11/50 38/50
|
Female Rats: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Kidney Tubular Cell:
ADENOMA 0/50 1/50 6/50; ADENOCARCINOMA 0/50 0/50 9/50; COMBINED 0/50 1/50 15/50
- Large Intestines:
ADENOMATOUS POLYP 0/46 0/50 7/47; ADENOCARCINOMA 0/46 0/50 6/47
|
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Kidney Tubular Cell:
ADENOMA 1/49 2/50 6/50; ADENOCARCINOMA 0/49 0/50 4/50; COMBINED 1/49 2/50 9/50
|
Female Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
ADENOMA 1/50 13/48 23/50; CARCINOMA 2/50 5/48 10/50
|
